Our research addresses the morphological consequences of growth factor
signaling and receptor tyrosine kinase trafficking in the nervous
system. We study fundamental neurobiological phenomena such as neurite
outgrowth and glial proliferation by mainly applying cellular methods
combined with high-resolution imaging. Fibroblast growth factor (FGF)
receptor signaling is in the focus of our projects. We have demonstrated
that blocking FGF induced negative feedback inhibitors such as Sprouty2
promotes axon regeneration and neuronal survival in neurological
disease models of the peripheral and central nervous system.
