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Neuroanatomy, Medical University Innsbruck

Our research addresses the morphological consequences of growth factor signaling and receptor tyrosine kinase trafficking in the nervous system. We study fundamental neurobiological phenomena such as neurite outgrowth and glial proliferation by mainly applying cellular methods combined with high-resolution imaging. Fibroblast growth factor (FGF) receptor signaling is in the focus of our projects. We have demonstrated that blocking FGF induced negative feedback inhibitors such as Sprouty2 promotes axon regeneration and neuronal survival in neurological disease models of the peripheral and central nervous system.

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